1ETE, 3QS7, 3QS9232314256ENSG00000090554ENSMUSG00000110206P49771P49772NM_001204502NM_001204503NM_001278637NM_001278638NM_001459NM_013520NP_001191431.1NP_001389764NP_001389765NP_001389766Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.

In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors.

The same paper suggested that FLT3L release was caused by stimulation of mast cells with uric acid, produced from a precursor secreted by the plasmodium parasite.

[11] In situ vaccine (ISV), combining Flt3L, local radiotherapy, and a TLR3 agonist (poly-ICLC), could recruit, antigen-load and activate intratumoral cross-presenting dendritic cells (DCs) in indolent non-Hodgkin’s lymphomas (iNHLs) treatment (clinical trial: NCT01976585).

[12] In this study, intratumoral Flt3L was able to (1) induce the accumulation of large numbers of TLR3+ DCs in the tumor and (2) mediate, together with local irradiation, cross-presentation of TAA by DCs in vitro and in vivo.