The auberge is located at Castile Place, close to Saint James Cavalier, the Malta Stock Exchange, and the Upper Barrakka Gardens.

Built in the Baroque style under the magistracy of Portuguese Grand Master Manuel Pinto da Fonseca in the 1740s, it replaced a 1574 building erected to house knights of the Order of Saint John from the langue of Castile, León and Portugal.

[3][4] The original Auberge de Castille was dismantled and completely rebuilt in the Spanish Baroque style between 1741 and 1744, during the magistracy of Grand Master Manuel Pinto da Fonseca.

[5] The new building was built to designs of Andrea Belli, and construction was supervised by capomastro Domenico Cachia.

The auberge subsequently became a headquarters for the French forces, and later housed a Commission for National Property.

A signalling station with a large aerial was installed on the roof in 1889 to liaise with warships of the Mediterranean Fleet moored in the Grand Harbour.

[2] Auberge de Castille is built in the Baroque style, and it is a two-storey building with a rectangular plan and a central courtyard.

[2][14] The main entrance is approached by a flight of steps, and the doorway is flanked by columns which support a trophy of arms and a bronze bust of Grand Master Manuel Pinto da Fonseca.

[23] Auberge de Castille was depicted on two commemorative coins minted in 2008 by the Central Bank of Malta.