Wisberg made his career as a screenwriter, director, and producer with credits in more than 40 films including The Big Fix, The Man from Planet X, Hercules in New York, The Neanderthal Man, Captive Women, Port Sinister and Captain Kidd and the Slave Girl.
Three of his early screenplays were World War II films: Counter-Espionage and Submarine Raider in 1942 and They Came to Blow Up America in 1943.
Wisberg's 1945 film The Horn Blows at Midnight starred the comedian Jack Benny.
Production credits for Mid-Century Film include, The Man From Planet X (1951), Return to Treasure Island (1954) and Murder Is My Beat (1955).
Wisberg was the author of several books, including Patrol Boat 999, Savage Soldiers, This Is the Life and Bushman at Large.