A subdistrict of the Uptown/Carrollton Area, its boundaries as defined by the New Orleans City Planning Commission are: South Claiborne Avenue to the north, Jefferson Avenue to the east, the Mississippi River and Magazine Street to the south, and Lowerline Street to the west.

The area is also known as the "University District," as it is also home of Tulane and Loyola Universities, as well as the former St. Mary’s Dominican College (now a satellite campus of Loyola), and Newcomb College (now part of Tulane).

The Audubon neighborhood was also the home of the original campus of Leland University.

[2] According to the United States Census Bureau, the district has a total area of 2.28 square miles (5.9 km2).

Areas of note are the houses that line St. Charles Avenue and the gated community Audubon Place.