He was born to Johann von Wörndle, Building Manager at the Hofburg (Imperial Palace).
Under the influence of one of his instructors, Joseph von Führich, he became an admirer of the Nazarene movement.
As an employee of Peter von Cornelius, he was involved in the creation of kartons for the "Campo Santo", a burial plot at the home of King Friedrich Wilhelm IV in Berlin.
They had a son, who died in childhood, and a daughter, Paula, who became a nun ("Mother Felicitas") in the Order of St. Ursula.
His most notable works include the frescoes in the chapel at Ambras Castle, and at the parish church of St. Laurentius in Wörgl.