He was born in Enfield Road, Kingsland, London, on 20 August 1843 into a Congregationalist family, the son of Samuel J. Wilkins, a schoolmaster in Brixton, and his wife, Mary Haslam, of Thaxted, Essex.
Entering St John's College, Cambridge with an open exhibition in October 1864, he became a foundation scholar in 1866.
[1] At Manchester Wilkins promoted female education, and lobbied for a department of theology.
In 1903, after 34 years' tenure of the Latin professorship, a weak heart compelled him to resign, whereupon he became professor of classical literature.
[1] On 26 July 1905, Wilkins died at Rhos-on-Sea in North Wales, and was buried in the cemetery of Colwyn Bay.
[1] Wilkins dedicated his edition of the De Oratore to the University of St Andrews, which conferred on him an honorary degree in 1882.