He has previously played in Major League Baseball (MLB) for the Pittsburgh Pirates, Tampa Bay Rays, and Detroit Tigers.

[2] Meadows was named a preseason First-Team High School All American by Rawlings and Perfect Game,[3] and he hit .535 with 14 doubles, one triple, four home runs and 28 RBIs in his senior season.

[2] Meadows also played football as a running back, wide receiver, and punter at Grayson where he was a teammate of Wayne Gallman and Robert Nkemdiche.

[14] Meadows returned to Indianapolis for the 2017 season,[15] where he posted a .250 batting average with four home runs and 36 RBIs in 72 games.

[21] On July 31, 2018, Meadows was traded to the Tampa Bay Rays, along with Tyler Glasnow and a player to be named later, later revealed to be Shane Baz, for Chris Archer and was optioned to Triple-A Durham.

[23] On July 16, 2020, Meadows was placed on the injured list after he tested positive for COVID-19, which caused him to miss the beginning of the abbreviated 2020 season.

On April 4, 2022, Meadows was traded to the Detroit Tigers in exchange for Isaac Paredes and a competitive balance round B pick in the 2022 MLB draft.

[27] After leaving the Tigers early in the season due to vertigo and later COVID-19, Meadows returned to the team in June only to go on the injured list again with tendinitis in his Achilles.

He would not return to the Tigers the rest of the season, adding that he was suffering from mental health issues in addition to his physical ailments.

On November 25, 2022, the Tigers and Meadows agreed on a one-year, $4.3 million contract for the 2023 season, avoiding salary arbitration.

The Tigers president of baseball operations Scott Harris issued a statement supporting Meadows' decision to step away from the game to seek help.