Regarded as a four-star recruit by Rivals.com, Seferian-Jenkins was ranked as the second-ranked tight end prospect in his class, behind Nick O'Leary and ahead of Jace Amaro.

[7] Upon completing his sophomore season, he had already set Washington records with 110 receptions, 1,390 receiving yards, and 13 touchdowns for the tight end position.

[9] Head coach Steve Sarkisian announced the next day that Seferian-Jenkins will have to undergo surgery to repair the broken pinkie.

[9] Following Washington's 31–16 victory in the 2013 Fight Hunger Bowl, he announced he would leave school early and enter the 2014 NFL draft.

[29] On March 15, 2017, Seferian-Jenkins was suspended the first two weeks of the 2017 season for violating the NFL Policy and Program for Substances of Abuse.

[30] During Week 6 against the New England Patriots, Seferian-Jenkins was thought to have fumbled inches from the endzone, resulting in a touchback.

The call was controversial, since he retained possession going to the ground and only momentarily appeared to shift the ball as he crossed the goal line, but ultimately the error loomed large, as the Jets lost the game 17–24.

[37] On February 18, 2019, the Jaguars declined the option on Seferian-Jenkins' contract, making him a free agent at the start of the new league year.

[42][43] The football team suspended Seferian-Jenkins for one game, the Huskies' 2013 season opener against Boise State.

[45] In May 2017, Seferian-Jenkins opened up regarding his struggles with alcohol, and indicated that he had sought help by attending rehab on an outpatient basis.

[47] On January 31, 2022, Seferian-Jenkins was arrested for fourth-degree assault, felony harassment and interfering with the reporting of domestic violence.