Andrews has been elected to the Pro Bowl three times and was named to the 2021 All-Pro Team after setting the Ravens' single-season record for receptions and receiving yards.

[11] In early January 2018, it was announced that Andrews would forgo his senior year at Oklahoma in favor of the 2018 NFL draft.

[13] On March 14, 2018, Andrews participated at Oklahoma's pro day, but chose to stand on his combine numbers and only performed positional drills.

At the conclusion of the pre-draft process, Andrews was projected to be a second round pick by NFL draft experts and scouts.

[14] He was ranked as the fourth best tight end prospect in the draft by DraftScout.com, Scouts Inc., NFL analyst Mike Mayock, and Sports Illustrated.

[22] Throughout training camp, Andrews competed to be a starting tight end against Hayden Hurst, Nick Boyle, and Maxx Williams.

Head coach John Harbaugh named Andrews the fourth tight end to start the regular season, behind Hurst, Williams, and Boyle.

[23] In the season opener against the Buffalo Bills, Andrews made his NFL debut and had three receptions for 31 yards in the 47–3 victory.

[citation needed] In Week 1 against the Miami Dolphins, Andrews had eight catches for 108 yards and one touchdown as the Ravens won 59–10.

[34] In Week 3 against the Kansas City Chiefs, Andrews caught three of his eight targets and dropped a potential touchdown pass in the end zone during the 20–34 loss.

[35] Andrews rebounded in the following week’s game against the Washington Football Team, catching three passes for 57 yards and two touchdowns during the 31–17 win.

[42] In Week 5 against the Indianapolis Colts, Andrews caught 11 of 13 targets for 147 yards and two touchdowns as well as two two-point conversion receptions (all career-highs), helping the Ravens to rally and win in overtime 31–25.

In Week 14, Andrews recorded 11 receptions (tying his career-high from earlier in the season) for 115 yards and a touchdown in a 22–24 loss to the Browns.

[52] Andrews recorded his second 100-yard performance in a Week 6 20–24 loss to the New York Giants, finishing the game with seven receptions for 106 yards and a touchdown.

After the game, it was announced he had suffered a cracked fibula and an ankle ligament injury, sidelining him for the rest of the regular season.

[63] Andrews was activated off of injured reserve on January 26, 2024 ahead of the AFC Championship game against the Kansas City Chiefs.