Accordingly, this side is of lower quality than the other; the widening of the road to three lanes has necessitated the removal of the emergency lane, and a reduction of all lanes to less than 3.75 m (12.3 ft) - this is less than the regulations of the Italian highway code, and has in turn caused a reduction of the speed limit to 80 km/h (50 mph) for most of the section between Albisola and Genoa Voltri.

On 14 August 2018, a section of the Ponte Morandi bridge that formed part of the A10 collapsed during a storm, killing 43 people.

Much of the route is built on hillside, with a series of viaducts and tunnels; for this reason, the entire motorway requires paying a toll charge (one of the most expensive in Italy).

Until the nineties, the border was marked by a change of stripe colour, from yellow to white, alongside a sign in the tunnel indicating the precise location of the border—this is now gone, although its former location can still be discerned from a change of lighting systems, and the different thicknesses of asphalt.

In the opposite direction, the A10 intersects with the A6, towards Turin, the A26, towards the Po Valley, Switzerland, and other major cities in the north of Italy, before finally joining the A7, towards Milan and Tuscany.