The next step for the fulfillment of the project was the foundation of Autostrada del Brennero S.p.A., on 20 February 1959, that two years later was given the concession for the building and the following management of the highway.

[1] After the opening of other segments, the highway could be considered as definitively completed on 11 April 1974, with the inauguration of the section between Chiusa and Bolzano, resulting in the most complicated one due to the complex infrastructural and engineering work.

To avoid these problems, it is suggested and incentivized the use of intermodal freight transport for the heavy vehicles, taking them onto specific wagons or boxcars, and the conveyance abroad from Verona by railway.

A22 guardrails, whose brown colour is very typical, are made in Corten Steel, an alloy showing elevated corrosion resistance rates and high mechanical strength.

The highway is 315 km long: the track begins nearby Modena, at the junction with Autostrada A1, and vertically crosses the whole Northern Italy, finally reaching at the Brenner Pass, along the Austrian border.

A22 highway, inside the network of European roads, is part for its entire track of the north–south route E45, connecting Karesuando and Gela.

Castle of Avio Monte Baldo - Prà Alpesina [it] della Valsugana delle Dolomiti - Fiemme Valley e Fassa Valley della Val di Non - Non Valley e Val di Sole della Val di Cembra In the section between Trento Sud and Rovereto Nord, a pilot project of the so-called "third dynamic lane", which includes the use of the breakdown lane as a normal drive lane when occurring particular situations such as traffic congestions.

[9][10] The project about the elongation of the A22 heading South, from the junction of Campogalliano to Sassuolo, 14 km long and provided with 6 tollbooths, was approved in 2005 by ANAS Governing Body.

[11] The beginning of the work, which was subcontracted to the temporary enterprise association Autocs (made up by Autostrada del Brennero spa, Coopsette, Impresa Pizzarotti & C., Cordioli, Edilizia Wipptal, Oberosler, and Consorzio stabile Coseam Italia), is due in May 2018.

Two viaducts are planned to be built to cross river Secchia (814 m) and to overpass via Emilia and Milano-Bologna railway beam (621 m), and two underground tunnels to shield the natural oasis in Colombarone di Formigine, in addition to 15 underpasses and 12 flyovers for the secondary traffic stream.

[12] Ti.Bre project (Italian acronym for Tyrrhenian-Brenner) includes the lengthening of highway A15 La Spezia-Parma northbound, from Fontevivo (Parma Ovest) to Nogarole Rocca tollbooth on A22, consisting of 85 km in total.

In particular, in the city of Rovereto, not being served by its own ring road, often occur long queues and traffic jams, frequently causing delays and accidents.

After prolonged hesitations by both the province and A22, led respectively by Luis Durnwalder and Silvano Grisenti, in 2013 the works for the realisation of the hydrogen production plant got underway, despite the fact that yet in 2012 no decisions were made.

In summer 2014, the plant was finished, supplying a new fuel station nearby Bolzano Sud tollbooth, inaugurated at the end of November.