The Autovía A-42 (also known as Autovía de Toledo) is a Spanish autovía which connects Madrid to Toledo.

It was built in the mid-1980s as an upgrade of the N-401 road between the two cities, and received the A-42 designation in 2003 as part of the general renumbering of Spanish autovías.

In the mid-2000s, the Autopista AP-41 was built to supersede the A-42, though the autovía is still regularly used.

Beyond Toledo, the A-42 continues through the community of Castilla–La Mancha to Tomelloso as the CM-42, itself an upgrade of the CM-400.

On May 9, 2006, the City of Getafe signed an agreement with the Ministry of Public Works to move the road to make it pass through Getafe.