Asprilla played professionally in the minor leagues from 1999 to 2006 in the Pittsburgh Pirates and Philadelphia Phillies organizations.

He split the 2002 season between three teams - the Crosscutters, the Hickory Crawdads and the Lynchburg Hillcats - hitting a combined .238 with six home runs and seven stolen bases in 85 games.

Asprilla split the 2001 season between three teams as well - the Crawdads, the Hillcats and the GCL Pirates - hitting .277 with four stolen bases in 52 games, combined.

He signed with the Phillies following the 2005 season, and he spent 2006 with two of their farm teams - the Lakewood BlueClaws and the Clearwater Threshers.

In the 2007 Pan American Games, Asprilla went four for 11 with two RBI, and in the 2007 Baseball World Cup he went two for 13.