[1] Durango made his professional debut that same year, playing for the San Diego Padres Rookie-level affiliate.

In 2008, he split time between Class-A, with the Fort Wayne Wizards, and High-A, with the Lake Elsinore Storm, before being added to the Padres' 40-man roster after the season.

Durango began 2009 with the San Antonio Missions in Double-A, but ended up working his way up to the majors, making his debut with the Padres on September 15.

To begin 2011, Durango played for the Padres new Triple-A affiliate in Tucson before being designated for assignment in late June.

He was named to the Arizona League All–Star team after the season, along with teammates Cedric Hunter and Rayner Contreras.

[10] Durango started the 2008 season with the Fort Wayne Wizards of the Midwest League, playing in 93 games for the club and hitting .305 with 14 steals.

He remained with Fort Wayne until August 12, when he was called up to the Lake Elsinore Storm, San Diego's High–A affiliate.

[2] Following the season, he joined the Algodoneros de Guasave of the Mexican Pacific League after Kit Pellow, a first baseman, was kicked off the team.

[15] Prior to the 2009 season, Grady Fuson, the Padres vice president of scouting and player development, said about Durango, "He's our little Juan Pierre.

[31] On June 2, after playing six games and hitting .385 with two runs batted in, he was optioned back to Portland with Scott Hairston taking his spot on the roster.

[34] For the third time that season, San Diego called Durango up to the major leagues on August 21,[35] however, he was sent back down again a week later.

[26] Following the season, he joined the Bravos de Margarita of the Venezuelan Professional Baseball League, but injured his wrist in early December.

[38] Durango started off the 2011 season with the newly relocated Tucson Padres, hitting for a .243 batting average with 10 stolen bases in 61 games before he was designated for assignment on June 21, making room for Josh Spence on the 40-man roster.

[39] Durango was claimed off waivers by the Houston Astros on June 29, and assigned to the Triple-A Oklahoma City RedHawks.

[40] After the trades of Hunter Pence and Michael Bourn, the Astros recalled Durango from Triple-A on July 31.

[26] Durango signed a minor league contract with the Chicago White Sox on April 3[26] and began the 2013 season with the Triple-A Charlotte Knights.

On July 6, 2013, Durango signed with the Rojos del Águila de Veracruz of the Mexican League.