As of November 2021, the theatre has been refurbished and advertised as the Kit Kat Club while it is hosting a revival of the musical Cabaret.

Farr's first production was unsuccessful, and so she prevailed upon her friend, George Bernard Shaw, to hurry and make his West End début at the theatre with Arms and the Man in 1894.

W. Somerset Maugham's Home and Beauty premièred at the Playhouse on 30 August 1919, running for 235 performances, and Henry Daniell appeared here in February 1926 as the Prince of Karaslavia in Mr. Abdulla.

The stage also hosted live performances by KISS, Queen, Led Zeppelin, The Who, The Beatles and The Rolling Stones.

The following year, the theatre was offered commercial sponsorship by a financial services' company, and for a while it was known as the MI Group Playhouse.

That year Cooney staged the West End premiere of his latest farce It Runs in the Family at the Playhouse.

In 1996, Cooney sold the Playhouse to American investment banker Patrick Sulaiman Cole, whose first production was a critically acclaimed revival of Henrik Ibsen's A Doll's House in 1996, directed by Anthony Page and starring Janet McTeer.

This was followed by Sulaiman Cole's production of a first ever West End Snoo Wilson premiere, "HRH", directed by Simon Callow, about the British Royal Family's Duke and Duchess of Windsor, which opened the day after the death of Diana, Princess of Wales.

American theatrical producers Ted and Norman Tulchin's Maidstone Productions purchased the theatre at the end of 2002,[4] with the venue managed by ATG Entertainment.

The Playhouse hosted Richard Eyre's 2003 Olivier Award-winning production of Vincent in Brixton, starring Clare Higgins; Eyre's 2005 production of Hedda Gabler, starring Eve Best; and Megan Dodds in a transfer of My Name Is Rachel Corrie by Alan Rickman and Katharine Viner in 2006.

More recent successes include the musical Dancing in the Streets, The Adventures of Tintin based on the famous comic-book detective, The Harder They Come, and La Cage Aux Folles.