The avenue is intersected by: The closest metro stations are: On 2 March 1864, the Avenue d'Iéna replaced the former Rue des Batailles, which ran between the Avenue Albert-de-Mun and the Place d'Iéna.

The Rue des Batailles had been a street in the village of Chaillot, engulfed by the expanding Paris in 1786.

The street housed several hospitals and a private lunatic asylum was set up in the house once occupied by the Chevalier Pierre Bayard du Terrail.

The chemist Charles Derosne (1779–1846), worked in 7 rue des Batailles at the extraction of sugar from sugarbeet.

On 20 December 1961, the name Place de l'Uruguay was given to the intersection of the Rue Galilée and the Rue Jean Giraudoux with the avenue.