A first version of the St. Sebastian panel was offered to Duke Alfonso d'Este of Ferrara in compensation for Titian's late completion of his Bacchanalia.

The Duke declined the offer, and the early St. Sebastian was perhaps sent to Mantua, where one such painting is mentioned among the works of art sold by the Gonzaga to Charles I of England.

[2] The panels are: The work inspired several Renaissance painters from the Brescia area, including Savoldo and Moretto[3] The central scene depicts a triumphant risen Christ, high above, in a dark yellow and grey dawn sky.

The kneeling donor, Altobello Averoldi, the papal legate to Venice, is portrayed in profile, stylistically reminiscent of the depiction of Sigismondo de' Conti in Raphael's Madonna of Foligno.

The two upper panels make up an Annunciation, with the announcing angel on the left and the Virgin on the right, according to a tradition dating from the Middle Ages.

His figure is unrolling a cartouche with the Gospel words Ave Gratia Plena, the salutation of the archangel Gabriel to the virgin Mary.