[3] In November 2016, Synergy Aerospace announced a firm order for the purchase of 12 ATR 72-600s for the airline to be operated under the Avianca brand.

[6][7] The airline originally planned to operate passenger and cargo flights both internationally and within Argentina from a primary hub at Teniente General Benjamín Matienzo International Airport serving San Miguel de Tucumán, with a fleet of Airbus A320-200 aircraft.

However, by January 2019, Avianca Argentina's plans for international services were canceled, with its sole Airbus A320 to be returned to Avianca Brasil (later taken up by LATAM Brasil), as the Argentine airline cited rising operating costs due to the weakening of the Argentine peso relative to the strengthening United States dollar.

[9][10] By April 2019, Avianca Argentina was reported to be struggling, having cut its route network to two destinations from the five it had planned to operate from Buenos Aires, and employing as many as 80 pilots while the airline's fleet remained at two aircraft, out of the four aircraft it had originally planned to operate at the time.

[11] The airline's CEO Carlos Colunga described the conditions as "unsustainable" and attributed the operational difficulties to the strengthening US dollar and rising fuel costs.