[1][10] In March 2009, Roy began writing The Apothecary, a personal blog focusing on healthcare policy, particularly his opposition to the Patient Protection and Affordable Care Act.

[14] In 2014, he authored a proposal for health care reform through the Manhattan Institute, entitled Transcending Obamacare: A Patient-Centered Plan for Near-Universal Coverage and Permanent Fiscal Solvency.

In 2024, Roy joined the University of Pennsylvania's Center for Health Incentives and Behavioral Economics (CHIBE) external advisory board.

[24] Roy has been on the Board of Advisors for the National Institute for Health Care Management Foundation which he joined in 2014,[25] and Concerned Veterans for America.

[26] In July 2016, as quoted in a Vox article, Roy said that the Republican Party had "lost its right to govern, because it is driven by white nationalism rather than a true commitment to equality for all Americans.