It began operations in March 2015 with flights from Caracas to Barinas, Valera as well as Curaçao.

In 2012, after the bankruptcy and subsequent restoration of Avior Airlines that took place between 2007 and 2009, company executives proposed the creation of a regional subsidiary that would cover the demand for all destinations previously operated by its parent company.

[4] Avior Regional started flights to its first international destination, Curaçao, on July 16, 2015.

[5][6] Since December 2, 2016, the airline has not provided commercial operations, it specified that the suspension was due to a restructuring with the purpose of improving air connectivity in regions to which Barinas and Valera offered services.

[7] Avior Regional flies to the following destinations as of July 2015[update]: The airline operated the following aircraft as of September 2016:[3][8][9]