Before entering politics, Jorbenadze worked as a doctor; in this capacity, in 1992 he was called to take up the post of deputy minister of health.

[citation needed] He left the cabinet briefly the following year, but soon rejoined it as health minister.

[2] When President Shevardnadze dismissed his cabinet, in the aftermath of a controversial storming of a television station by security agents,[3] Jorbenadze was appointed head of the cabinet in December 2001.

[2] He resigned his position during the November 2003 Rose Revolution.

In 2011, he became the chairman of the supervisory board for Chapidze Emergency Cardiology Center in Tbilisi.