[2] Coll-Seck is the author of over 150 scientific publications and communications on diverse subjects (including malaria, measles, meningitis, tetanus, typhoid fever, tuberculosis, HIV/AIDS and cardiovascular diseases), and is a member of over 20 professional societies and organizations.

She led the Department of Policy, Strategy and Research, the largest department within UNAIDS consisting of a diverse group of physicians, nurses, researchers, and other international policy and technical experts "best practice" guidance to assist governments and civil society in mounting their national and community responses to the global AIDS epidemic.

[citation needed] Awa Marie Coll-Seck was subsequently named Director of the UNAIDS Department of Country and Regional Support, where she coordinated and mobilized the UN system response to the epidemic while supervising UNAIDS staff serving at four regional offices and at country-level offices throughout Africa, Asia, Eastern and Central Europe, and Latin America and the Caribbean.

[6] In January 2016, Coll-Seck was appointed by United Nations Secretary-General Ban Ki-moon to the High-level Advisory Group for Every Woman Every Child.

[12] From 2016[13] until 2018[citation needed], she served on the Guttmacher-Lancet Commission on Sexual and Reproductive Health and Rights (SRHR), as well as the board of African Constituency Bureau of The Global Fund to Fight AIDS, Tuberculosis and Malaria.

[14] On January 19, 2017, Coll-Seck participated in an event called “The Next Frontier in Global Financing: High-Impact Solutions for Women and Children” in Davos, Switzerland.

[15] The event also featured Bill Gates as a speaker, and was sponsored by the Global Financing Facility, World Bank Group and Merck.