During the 1950s, Anderson moved his young family, including wife Helena,[1] to Bogotá, Colombia where he worked in theater.
Anderson made his debut in Puerto Rican television with a sitcom named Qué Pareja, a local version of I Love Lucy.
Early in his career, he starred in a novela titled Cuando los hijos condenan in which Anderson and co-star Marta Romero shared the first on-screen kiss in the history of Puerto Rican television.
In his last 20 years, Anderson remained one of the leading actors in Puerto Rico and continually acted in major local and international productions, including a small role as the bank director in the Sylvester Stallone thriller Assassins.
Anderson (lyrics) and Tony Croatto (music) co-wrote Agüeybaná, a song dedicated to the memory of the most important Taino "Cacique" of the pre-colonial Puerto Rico, recorded by Nelly y Tony and later by Haciendo Punto En Otro Son, which became a major hit in the 70s.