[2] At 2.01 m (6 ft 7 in) tall[3] and 101 kg (223 lb), he plays at the shooting guard and small forward positions.

Axel Toupane is a graduate of Bocconi University, HEC Paris, and Emlyon Business School.

On July 23, 2015, Toupane signed with the Toronto Raptors after having averaged 4.3 points and 1.7 rebounds in three Summer League games for the team.

[9] On November 19, he made his debut for the Raptors 905 in a 109–104 loss to the Maine Red Claws, recording 17 points, 10 rebounds, four assists and one steal in 30 minutes of playing time.

[10] On March 3, 2016, Toupane signed a 10-day contract with the Denver Nuggets after having averaged 14.6 points, 5.6 rebounds, 3.6 assists and 1.0 steals over 32 games in the D-League.

[11] The next day, he made his NBA debut in a 121–120 loss to the Brooklyn Nets, recording one rebound in five minutes off the bench.

[29] On December 3, 2020, Toupane signed a training camp deal with the Golden State Warriors.

[31] On January 12, 2021, Toupane was included on the roster of the Warriors' affiliate, the Santa Cruz Warriors, for the 2020–21 season that took place at the ESPN Wide World of Sports Complex of Walt Disney World Resort, located near Orlando.

[38] On January 6, 2022, Toupane marked his return to France, signing with Paris Basketball of the LNB Pro A until the end of the 2023–2024 season.

[41] On August 29, 2024, he signed with Diablos Rojos del México of the Liga Nacional de Baloncesto Profesional,[42] he didn't play any games for the team.