Axelle Laffont participated in La Matinale d'Arthur from 1996 to 1999, but became known by intervening in La Grosse Émission from 1999 to 2000 and then presenting in 2000 and 2001 a very special weather and staggered in the show Nulle part ailleurs on Canal+, based on sketches and burlesque disguises.

She makes a one-woman show La Folie du spectacle on a production by Serge Hazanavicius and Maurice Barthelemy of Robins des bois from 2002 to 2005.

From September 2007 to January 2008, she regularly appeared in the program On n'est pas couché hosted by Laurent Ruquier on Saturday nights on France 2.

In September 2015, she returned on stage with the one woman show HyperSensible, directed by Charles Templon.

From 2013 to 2015, she was in a relationship with Cyril Paglino, a former contestant on the reality TV show Secret Story.