[3][2] After eight days docked to the ISS, the Dragon crew capsule Freedom undocked and returned to Earth twelve hours later.

[6] The Saudi Space Agency purchased the other two seats on the flight and named astronauts Ali AlQarni and Rayyanah Barnawi to be the Mission Specialists.

[8][9] On 11 January 2022, Axiom announced Italian Air Force Colonel Walter Villadei as the company's first international professional astronaut.

[13] Axiom 2 lifted off on 21 May 2023 from Launch Complex 39A at Kennedy Space Center, onboard a Falcon 9 Block 5 rocket.

During the mission, the crew performed public outreach activities along with scientific research, including studies into the effects of microgravity on stem cells and other biological experiments.