[1] He served as attorney general and Minister of Justice of Ghana in the John Agyekum Kufour administration.
[4] After obtaining his GCE Advanced Level certificate he was admitted to the University of Ghana in 1976 to pursue a degree in law.
[4] He served as secretary and later as president of the Greater Accra Regional Bar Association for three consecutive terms, spanning between 1998 and 2001.
[3] In the corporate, Otoo has served as a member of the Interim Management team of Sabat Motors, chairman of the board of directors of State Insurance Company (SIC).
Ayikoi Otoo was appointed as the attorney general and minister of justice by President John Agyekum Kufour in 2005 to succeed Papa Owusu-Ankomah.
[11] In March 2017, President Nana Addo Dankwa Akufo-Addo appointed Ayikoi Otoo as Ghana's High Commissioner to Canada.
[15] However, just days to the Party's National Delegates' Conference in July 2022, he announced his withdrawal from the race despite being cleared by the vetting committee for the contest.