[7] In 2015, Safadi was appointed as a member of the board of directors of the Al-Mamlaka TV channel.

[8] He founded in 2014 and is the Chief Executive Officer of Path Arabia, a political and communication strategy company and consultancy that operates out of Abu Dhabi.

[7] Safadi was appointed Minister of Foreign Affairs on 15 January 2017, replacing Nasser Judeh.

[12] On 12 October 2020, he was also appointed Deputy Prime Minister in Bisher Al-Khasawneh's Cabinet.

[13] In January 2022, Safadi met with United States Secretary of State Antony Blinken in Washington, D. C., to discuss bilateral relations, economic cooperation, and issues in the Middle East including Syrian crisis, two-state solution, and support of Iraq.