Ayssènes (French pronunciation: [ɛsɛn]; Occitan: Aissenas) is a commune in the Aveyron department in the Occitanie region of southern France.

From the dam the Tarn continues south-west to eventually join the Garonne just west of Moissac.

The Ruisseau de Vernobre rises in the north of the commune and flows south, gathering many tributaries, to join the Tarn.

Prestigious guests stayed at this location including the King of France, Charles VII, on 13 May 1437 while returning from Languedoc where he had been to restore order.

The Captain of the garrison made a ploy and the duke's army retreated towards the plateau of Saint-Victor which was where the garrison captain attacked the camp at night - taking fifty horses and capturing several soldiers.