Back in high school, he played football, and during his university days, he was part of a rakugo study group.

In 2015, he played Jun'ichi Amamiya in a stage adaptation of The Black Lizard alongside Akihiro Miwa.

[3] In 2014, Ayumu Nakajima landed his first regular TV role in the series Hanako to Anne, where he played Ryūichi Miyamoto.

[6][7] From November 2021, he appeared in the Hong Kong film Anita, a biographical film about Anita Mui, which was released mainly across Asia (though it did not hit theaters in Japan, the Director's Cut version started streaming on Disney+ in Japan from April 2022).

[8] In 2022, he snagged the Best Supporting Actor award at the 35th Takasaki Film Festival for his roles in Wheel of Fortune and Fantasy.