He is a member and Division Deputy Chief of Padang Besar of the United Malays National Organisation (UMNO), a component party of the BN coalition.
On 13 June 2018, Azizan was appointed as the Perlis State EXCO Member in charge of Housing, Local Government, Hawkers, Small Business Development, Domestic Trade, Co-operatives, Consumer Affairs, Entrepreneur Development and Small–Medium Industries by Menteri Besar Azlan.
He won the seat and was elected into the Perlis State Legislative Assembly as the Santan MLA after defeating Che Mazlina Che Yob of Pakatan Harapan (PH) and Baharuddin Ahmad of Gagasan Sejahtera (GS) by a majority of 949 votes.
In the 2022 Perlis state election, Azizan was renominated by BN to defend the Santan seat.
He lost the seat and was not reelected as the Santan MLA after losing to Mohammad Azmir Azizan of Perikatan Nasional (PN) by a minority of 2,108 votes.