[1] Her grandfather, Brad Johnson, who died before her birth, was an actor known for his role as deputy sheriff Lofty Craig in the Western series, Annie Oakley (1954–1957), as well as a real estate developer in Los Angeles.

In the episode "Help" she plays Cassie Newton, a teen girl at Sunnydale High who possesses the power of precognition and who foresees her own death, and whom Buffy tries to help.

She has played Susie Keaton in four episodes of CSI: Miami and has made guest appearances in shows such as Smallville and Judging Amy.

Skye has also played parts in movies like Bandits (with Bruce Willis and Cate Blanchett), The Salton Sea (with Val Kilmer) and Red Dragon (with Anthony Hopkins).

In 2008, she had a major part in the American remake of the Japanese horror movie One Missed Call, which was released in the US on January 4, 2008.