As a generalisation, indolent lymphomas respond to treatment and are kept under control (in remission) with long-term survival of many years, but are not cured.

Aggressive lymphomas usually require intensive treatments, with some having a good prospect for a permanent cure.

[1] Prognosis and treatment depends on the specific type of lymphoma as well as the stage and grade.

Early-stage indolent B-cell lymphomas can often be treated with radiation alone, with long-term non-recurrence.

The enhancer element of the immunoglobulin heavy locus, which normally functions to make B cells produce massive production of antibodies, now induces massive transcription of the fusion protein, resulting in excessive pro-proliferative or anti-apoptotic effects on the B cells containing the fusion protein.