Moore first achieved notoriety as the writer and co-creator of Hawaiian Dick, first published in 2002 by Image Comics.

In 2008, Warner Brothers optioned the unpublished graphic novel, Billy Smoke, from Oni Press, for development as a feature film.

Moore's debut for WildStorm Productions was Casey Blue: Beyond Tomorrow, a 2008 six-issue mini-series that was collected into a trade paperback in early 2009.

In 2010, WildStorm announced the forthcoming The Further Adventures of the Whistling Skull, an upcoming creator-owned title with artist Tony Harris, originally set to debut in 2011.

A new four-issue series called Savage, co-created by Moore and artist Lewis LaRosa, published by Valiant Comics, debuted in November, 2016.

There is always the chance that printing delays will get in the way of the intended delivery date, but we're committed to having the book in people's hands as a companion to ALOHA, HAWAIIAN DICK."

In a message to backers in November 2016, Moore claimed the digital files for the book were lost in a computer crash.