[7] Oni Press used the term "real mainstream," coined by Stephen L. Holland of the UK comic shop Page 45,[8] to suggest that the subject matter it publishes is more in line with the popular genres of other media, such as thrillers, romances and realistic drama.

For the most part, Oni Press avoids publishing superhero titles, unless interesting creators approach these concepts from an unusual angle.

[9] Oni Press publishes few comic books on an ongoing monthly basis - Marc Guggenheim's Resurrection, Antony Johnston and Christopher Mitten's Wasteland and Brian Hurrt and Cullen Bunn's Sixth Gun.

[citation needed] Several of their books have won the Eisner Award including: Bryan Lee O'Malley's Scott Pilgrim, Rick Spear and Chuck BB's Black Metal, Hope Larson's Grey Horses, and Greg Rucka's Whiteout: Melt and Queen & Country, with many more receiving nominations.

[11] Oni Press had a film and television production unit, Closed on Mondays, headed by Eric Gitter and located in Los Angeles, California.

[12] In 2016, the publisher launched Limerence Press, an imprint for erotic and sex-education comics, "focused on positive, diverse, and approachable stories that reflect a wide variety of emotional and intimate experiences".

[13] Oni Press underwent a reorganization in January 2018,[14] with Nozemack acting as founder and chief financial officer, Jones as publisher, Chu as vice president of creative & business development.

In June 2022, Virginian politicians Tim Anderson and Tommy Altman sued Kobabe and OLFPG over Gender Queer under state law, alleging that the graphic novel was "obscene for unrestricted viewing by minors".