After Prabhudass discerned his avocation to become a Priest, the Diocese of Dornakal led by V. S. Azariah sent him for ministerial formation to the United Theological College, Bangalore,[11] one of the affiliated seminaries of the Senate of Serampore College (University)[8] where he pursued a spiritual course leading to Bachelor of Divinity[8] between 1941 and 1945[12] during the Principalship of Max Hunter Harrison.
Other companions of Prabhudass during that period who were studying at varying intervals included A. E. Inbanathan, C. Arangaden, J. R. Chandran, S. J. Samartha, B. G. Prasada Rao and others.
Prabhudass was a Seminary Teacher at the Andhra Union Theological College (AUTC), Dornakal, teaching along with Eric J. Lott.
By 1959,[15] much before the integration of the AUTC into the Andhra Christian Theological College, Rajahmundry, Prabhudass had moved out to medical ministry as a Chaplain at the CSI-Mission Hospital,[16] Phanigiri.
[8] Prabhudass was also part of the literary circles of the college and was made a member of the editorial committee of the UTC-Gurukul Alumni Journal.
Based on the communication from the Bishop, Joshua Russell Chandran[22] Principal[2] relieved Prabhudass in 1977[2] enabling him to return to the Diocese of Dornakal in September 1977.
After ministering for nearly 5 years in the bishopric, Prabhudass vacated the Cathedra in Karimnagar in 1982[1] on attaining superannuation resulting in sede vacante following which the Church of South India Synod led by I. Jesudasan, then Moderator of the Church of South India Synod appointed G. B. Devasahayam[1] in 1982 to succeed Prabhudass.
In 2010, a mission focusing on the leprosy-afflicted living in the suburbs[31] of the twin cities of Hyderabad and Secunderabad in India was instituted to the memory of Prabhudass jointly by Christ the King and the Episcopal Diocese of Fort Worth (Episcopal Church)[31] where annual charity events[32] are taken up for creating awareness and mobilizing resources for the mission.