This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance.

This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system.

This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease.

It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis.

Alternative splicing of the 3'-end of this gene results in three products of undetermined function.