The station's initial output was very limited and even in 1931 the programme centre employed a staff of just three people, operating from a small studio over the Midland Bank in Queen's Road.

In 1986 33A&B Whiteladies Road were demolished to make way for a new development providing post-production facilities, a restaurant, library and headquarters offices for the South and West Region, as well as a new reception for Broadcasting House.

After being formally established here in 1957, the BBC Studios Natural History Unit moved to a new home in Bridgewater House, Bristol city centre, in 2022.

The Bristol portfolio of BBC Studios Factual Entertainment Productions was also relocated to Bridgewater House.

From 1986, the BBC leased warehouses on the Kingsland Trading Estate, and also (from 2002) on the Lawrence Hill Industrial Park, to provide facilities for Casualty when it was produced in Bristol.