Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.

Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

[5] Bcl2L12 expression is upregulated in most human glioblastomas.

[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.

This article on a gene on human chromosome 19 is a stub.