In 2006, the club reached the final of the EuroCup Challenge, where they were defeated by Ural Great Perm.

In the first season of the club, the team immediately finished in fourth place in the Ukrainian Basketball SuperLeague.

In the regular season, Khimik finished 30–0 and in the Playoffs the team won all its six games.

In 2016, Khimik repeated as national champions - winning the Ukrainian SL Favorit Sport (one of the two Ukrainian top tier basketball leagues).

Note: Flags indicate national team eligibility at FIBA-sanctioned events.