Filling a gap in what was a new research field, the journal was established in 2007 and is published by BioMed Central.

[2] In January 2019, the Editorial Board was informed that the journal was closing and no more submissions would be accepted after March 1.

[3] The last articles were published on 5 April 2019, but content is still archived in perpetuity from the homepage and PubMed Central.

Some notable research includes: The journal's impact factor in 2018 was 2.048, reflecting its influence and relevance in the field of systems biology.

[8] Although the journal is now closed, its archived content continues to serve as a valuable resource for researchers and scholars.