The E60 generation introduced various new electronic features, including the iDrive infotainment system, head-up display, active cruise control, active steering, adaptive headlights, night vision, lane departure warning and voice control.

The body of the E60 was made using aluminium for the front of the car, and steel for the passenger cabin and rear.

Optional features included an 8-inch LCD screen, GPS navigation, Sirius Satellite Radio (on North American-spec models), and DVD video playback.

iPod and USB integration, HD Radio (on North American-spec models), an auxiliary audio input jack (standard on 2008 and newer models), full voice control, and a multi-disc CD/MP3/DVD changer (mounted in the glove compartment).

On North American-spec models, a ten-speaker premium audio system with dual under-seat subwoofers and an amplifier was standard equipment, with a thirteen-speaker Harman Kardon "Logic 7" premium surround sound audio system available as an option on all models.

[4] Safety-related items include Dynamic Stability Control (DSC), adaptive headlights and night vision.

The iDrive controller in the centre console was also redesigned, and now integrated shortcut keys for frequently-used functions.

Over the E60's lifespan, the following features were added: Active Cruise Control with Stop & Go,[18] keyless entry ("comfort access"), LED taillights,[19] Lane Departure Warning[15] and Brake Force Display.

The only diesel model available at launch was the 530d, which used an updated "TÜ" version of the M57 engine found in the previous generation E39 5 Series.

[33] Built with ballistic steel, aramid, polyethylene and 21mm polycarbonate layered glass[34] it was certified at VR4 level of VPAM's Bullet Resistant Vehicle guidelines (1999).

[35] The armoured areas include the entire passenger cell, battery terminals and Engine Control Unit.

[41][42] The IIHS reported their side impact test would likely cause driver related rib fractures and/or internal organ injuries.

Styling changes were relatively subtle, and included revised headlights, tail lights and front bumper.

Other changes include adaptive headlights, LED rear lights, Lane Departure Warning,[46] night vision[47] and Brake Force Display.

[49] Complete knock-down assembly of German-produced kits took place in Thailand,[50] Egypt,[51] Russia[52] and Malaysia.