The E60 generation introduced various new electronic features, including the iDrive infotainment system, head-up display, active cruise control, active steering, adaptive headlights, night vision, lane departure warning and voice control.

It was sold in the saloon and wagon body styles, with most cars using the 7-speed SMG III transmission.

Optional features included an 8-inch LCD screen, GPS navigation, Sirius Satellite Radio (on North American-spec models), and DVD video playback.

iPod and USB integration, HD Radio (on North American-spec models), an auxiliary audio input jack (standard on 2008 and newer models), full voice control, and a multi-disc CD/MP3/DVD changer (mounted in the glove compartment).

On North American-spec models, a ten-speaker premium audio system with dual under-seat subwoofers and an amplifier was standard equipment, with a thirteen-speaker Harman Kardon "Logic 7" premium surround sound audio system available as an option on all models.

[4] Safety-related items include Dynamic Stability Control (DSC), adaptive headlights and night vision.

The iDrive controller in the centre console was also redesigned, and now integrated shortcut keys for frequently-used functions.

Over the E60's lifespan, the following features were added: Active Cruise Control with Stop & Go,[18] keyless entry ("comfort access"), LED taillights,[19] Lane Departure Warning[15] and Brake Force Display.

The only diesel model available at launch was the 530d, which used an updated "TÜ" version of the M57 engine found in the previous generation E39 5 Series.

[33] Built with ballistic steel, aramid, polyethylene and 21mm polycarbonate layered glass[34] it was certified at VR4 level of VPAM's Bullet Resistant Vehicle guidelines (1999).

[35] The armoured areas include the entire passenger cell, battery terminals and Engine Control Unit.

[41][42] The IIHS reported their side impact test would likely cause driver related rib fractures and/or internal organ injuries.

Styling changes were relatively subtle, and included revised headlights, tail lights and front bumper.

Other changes include adaptive headlights, LED rear lights, Lane Departure Warning,[46] night vision[47] and Brake Force Display.

[49] Complete knock-down assembly of German-produced kits took place in Thailand,[50] Egypt,[51] Russia[52] and Malaysia.