As with other models in the F-series range, the F800GT uses a 798 cc (48.7 cu in) parallel-twin engine, codeveloped by BMW and Rotax.

The engine has a 360° firing order which produces an exhaust note reminiscent of BMW's signature air-cooled boxer twins.

To counter the significant inertia produced by the pistons reciprocating, BMW devised a third vestigial connecting rod to a balance weight.

In the UK and now the US, factory options include heated grips, tire pressure monitoring system, onboard computer, LED indicators, anti theft alarm system, main centre stand, Automatic Stability Control (ASC), pannier fastenings, comfort seat, low seat, and Electronic Suspension Adjustment (ESA).

[6] Compared to its predecessor, the F800GT offers several new features, including:[1] power increase of 3.5 kW (5 hp); redesigned full fairing with improved wind and weather protection; introduction of optional Electronic Suspension Adjustment (ESA) and Automatic Stability Control (ASC); handwheel adjustment of rear suspension preload; 50 mm (2.0 in) longer rear swingarm; lighter cast aluminum wheels; new vibration-free handlebars with new generation switches and controls; updated instrument dials and standard fuel/temperature gauges; smoke grey turn indicators; increased load capacity (by 11 kg (24 lb); new exhaust system; new paint finishes; and a newly developed luggage system.