8034166557ENSG00000078898ENSMUSG00000027481Q8N4F0Q8C1E1NM_025227NM_025631NP_079503NP_079907BPI fold-containing family B, member 2, (BPIFB2) also known as bactericidal/permeability-increasing protein-like 1, (BPI-like 1) is a protein that in humans is encoded by the BPIFB2 gene.

[8] The BPI fold creates apolar binding pockets that can interact with hydrophobic and amphipathic molecules, such as the acyl carbon chains of lipopolysaccharide found on Gram-negative bacteria, but members of this family may have many other functions.

In humans, the BPIFB2 gene was first identified as a BPIL3 gene [5] whose encoded protein was called LPLUNC2 (long-palate lung and nasal epithelium clone 2),[11] but subsequently PLUNC proteins were classified as a subfamily of the BPI fold superfamily.

In particular, it is highly expressed in normal salivary glands and esophagus as well as in hypertrophic tonsils in humans.

[6] In chronic rhinosinusitis BPIFB2/LPLUNC2 levels are profoundly reduced which has been interpreted as a defect in the release of glandular innate defense molecules.