was founded in 1945 by Professor Trevor Bruttenholm to combat various occult threats uncovered in operations against Nazi Germany.

It initially had strong links to the United States Army Air Forces and was based at a military airbase in New Mexico, but in 1947 later relocated to a custom built facility in Fairfield, Connecticut.

Over the years, the Bureau has added several agents with "enhanced skills" to its ranks including Hellboy in 1952, Liz Sherman in 1980, and Abe Sapien in 1981.

After Katha-Hem was destroyed, the frog monsters dragged the Black Flame into a vast pit and the invasion appeared to come to an end.

A series of incidents—featured in The Warning, The Black Goddess, and King of Fear—saw the Bureau threatened by both an alliance of the frogs, the Black Flame, and creatures from the Hollow Earth, united to bring about an apocalypse and the birth of a new human race; and also the villain Memnan Saa, who abducted Liz in an attempt to use her powers to conquer the Earth so he could prevent the Apocalypse.

This crisis saw half of Munich destroyed, the Bureau discredited in the eyes of the American military, and Abe Sapien revealed to be an example of the next stage of the frog's evolution.

In the wake of this new crisis, the United Nations Security Council drafted the Bureau to work directly for them, with "blank cheque" funding.

A vision of the future shown in King of Fear showed the apocalypse had triumphed over this larger, more heavily armed B.P.R.D.

In the wake of the events of King of Fear, the world enters an apocalyptic era as natural disasters and vicious monsters crawl out of the Earth.

Society is pushed to the brink of madness as many new cults arise to worship the creatures, while other supernatural forces begin shifting their plans in response to the global chaos.

agents face their own struggles during this time - Johann claims revenge on Ben Daimio for the destruction of his new body, while Abe is shot in the head by a panicked psychic girl named Fenix.

Unfortunately, Zinco and the last remnants of Project Ragnarok inadvertently resurrect a new and more powerful Black Flame, who proceeds to take control of New York and reawaken many slumbering Ogdru Hem all over the globe.

Liz regains her powers and rejoins the B.P.R.D., while Johann transfers his spirit into the WWII Sledgehammer suit and together they fight the Ogdru Hem as they run rampant.