Babu Mohan debuted in the film Ee Prasnaku Baduledi, followed by Ahuthi (directed by Kodi Ramakrishna), Ankusam and then a comedy character in Mamagaru.

After this film, Babu Mohan and Kota Srinivasa Rao developed a comedy partnership and are one of most celebrated duos,[4] for which many producers created special characters.

Their films include Hello Brother, Varasudu, Allari Alludu, Inspector Ashwini, Pedarayudu, Paradesi, Appula Appa Rao and Jamba Lakidi Pamba.

He was first elected as an MLA in the 1998 by-elections and retained the seat in 1999 from Andole Assembly constituency in Medak district serving as a Minister for Labour in the N. Chandrababu Naidu's cabinet.

[8] On October 28, 2023, he announced that he will be resigning from the party, citing insult and deliberate exclusion, particularly by individuals like Kishan Reddy and Bandi Sanjay, as the reasons for his decision.