[2] H. coagulans has been added by the EFSA to their Qualified Presumption of Safety list[6] and has been approved for veterinary purposes as GRAS by the U.S. Food and Drug Administration's Center for Veterinary Medicine, as well as by the European Union, and is listed by AAFCO for use as a direct-fed microbial in livestock production.

[11] There is evidence from animal research that suggests that H. coagulans is effective in both treating as well as preventing recurrence of Clostridioides difficile associated diarrhea.

[12] Further, one animal research study showed that it can alter inflammatory processes in the context of multiple sclerosis.

[14] Spores are activated in the acidic environment of the stomach and begin germinating and proliferating in the intestine.

H. coagulans is often marketed as Lactobacillus sporogenes or a 'sporeforming lactic acid bacterium' probiotic, but this is an outdated name due to taxonomic changes in 1939.