The Zarya and Zvezda modules of the International Space Station, as well as Salyut 2, 3 and 5, and the Spektr and Priroda modules of Mir, were launched from Area 23.

On 2 July 2013, a Proton-M/DM-03 launched from Site 81/24 carrying three GLONASS navigation satellites.

Immediately after liftoff, the rocket began to pitch over, and rolled out of control.

The rocket fell close to the launch pad and exploded, the extent of any damage to Site 81 or the Baikonur Cosmodrome is unclear.

On 25 February 2020, Roscosmos announced that Site 81/24 will be deactivated by late 2022 or early 2023; any remaining Proton-M launches on the manifest after that time will be transferred to Site 200/39.