The complex was built in the 1960s as part of the Soviet crewed lunar programs, for use by the N1 rocket.

Following the dissolution of the Soviet Union the Energia and Buran programmes were cancelled, and the complex was abandoned.

The N1 made four flights, all of which were launched from Site 110, and all of which failed before the first stage had completed its burn.

[3] Both N1 pads at Site 110 were then rebuilt for launching Energia rockets[4] and adapted for crewed flights.

The only Energia launch from Site 110 occurred at 03:00 UTC on 15 November 1988, carrying the first Buran shuttle on an uncrewed test flight.